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Author: Omid Zad, MD

Recirculation Fraction Calculator

Recirculation fraction (RF) in ECMO (Extracorporeal Membrane Oxygenation) refers to the percentage of oxygen-rich blood that’s returned to the patient but then unintentionally drawn back into the ECMO circuit. This percentage shows how efficient the ECMO system is, as it reveals the mixing of oxygenated and non-oxygenated blood. The higher the recirculation fraction, the less effective the ECMO support becomes for the patient. To make sure the patient receives the best possible care, it’s essential to keep an eye on and minimize the recirculation fraction while they’re on ECMO therapy.


Recirculation Fraction (RF)= CPreO2 - CVO2) / (CPostO2 - CVO2) * 100

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Parkinson Disease

Parkinson’s disease is a chronic and progressive neurodegenerative disorder that affects millions of people worldwide. It was first described by James Parkinson in 1817, and since then, much progress has been made in understanding this condition. Parkinson’s disease is caused by the loss of dopamine-producing cells in the brain. Dopamine is a neurotransmitter that plays a vital role in regulating movement, and the loss of dopamine-producing cells results in the movement problems associated with Parkinson’s disease.

Etiology

The exact cause of Parkinson’s disease is unknown, but it is thought to be a combination of genetic and environmental factors. Age is also a significant risk factor for developing Parkinson’s disease, with the majority of cases being diagnosed after the age of 60.

Diagnosis

The diagnosis of Parkinson’s disease is typically made based on a combination of clinical symptoms and neurological examination. The four primary symptoms of Parkinson’s disease are:

  • Tremor
  • Rigidity
  • Bradykinesia (slowness of movement)
  • Postural instability.

A doctor may also order imaging studies, such as a computed tomography (CT) scan or magnetic resonance imaging (MRI), to rule out other conditions that may mimic Parkinson’s disease.

Treatment

Currently, there is no cure for Parkinson’s disease, but treatment options are available to manage the symptoms. Medications such as levodopa and dopamine agonists can help improve motor symptoms. Physical therapy, occupational therapy, and speech therapy can also help manage symptoms and improve quality of life. In advanced cases, deep brain stimulation (DBS) surgery may be an option.

Prognosis

The prognosis for Parkinson’s disease varies from person to person. The progression of the disease can be slow or rapid, and some people may experience more severe symptoms than others. With proper treatment and management, many people with Parkinson’s disease can maintain a good quality of life for many years.

Prevention

There is no known way to prevent Parkinson’s disease. However, some studies suggest that regular exercise and a healthy diet may reduce the risk of developing Parkinson’s disease.

Living with Parkinson’s Disease:

Living with Parkinson’s disease can be challenging, but there are several things that people with Parkinson’s disease can do to manage their symptoms and improve their quality of life. These include:

  1. Staying physically active with regular exercise
  2. Eating a healthy diet
  3. Taking medications as prescribed
  4. Participating in support groups and other community resources
  5. Keeping a positive attitude and staying engaged in activities

Taking Care of Patients with Parkinson’s Disease

Taking care of someone with Parkinson’s disease can also be challenging, but there are several things that caregivers can do to help. These include:

  1. Educating themselves about Parkinson’s disease and its symptoms
  2. Assisting with medications and doctor appointments
  3. Helping with physical therapy exercises and other activities of daily living
  4. Providing emotional support and participating in support groups
  5. Taking care of their own physical and emotional needs to avoid burnout.

In conclusion, Parkinson’s disease is a chronic and progressive neurodegenerative disorder that affects millions of people worldwide. While there is no cure for Parkinson’s disease, treatment options are available to manage the symptoms and improve quality of life. With proper care and management, people with Parkinson’s disease can maintain a good quality of life for many years.

References:

  1. DeMaagd, G., & Philip, A. (2015). Parkinson’s Disease and Its Management. Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis. Pharmacy and Therapeutics, 40(8), 504–532.
  2. DeMaagd, G., & Philip, A. (2015). Parkinson’s Disease and Its Management. Part 2: Introduction to the Pharmacotherapy of Parkinson’s Disease. Pharmacy and Therapeutics, 40(8), 504–532.
  3. National Institute of Neurological Disorders and Stroke. (2019). Parkinson’s Disease Information Page. Retrieved from https://www.ninds.nih.gov/Disorders/All-Disorders/Parkinsons-Disease-Information-Page
  4. Parkinson’s Foundation. (2021). Living with Parkinson’s. Retrieved from https://www.parkinson.org/Living-with-Parkinsons
  5. Schapira, A. H. V., Chaudhuri, K. R., & Jenner, P. (2017). Non-motor features of Parkinson disease. Nature Reviews Neuroscience, 18(7), 435–450. https://doi.org/10.1038/nrn.2017.62
  6. Shulman, L. M., Gruber-Baldini, A. L., Anderson, K. E., Vaughan, C. G., & Reich, S. G. (2008). The Evolution of Disability in Parkinson Disease. Movement Disorders, 23(6), 790–796. https://doi.org/10.1002/mds.21920
  7. Wirdefeldt, K., Adami, H.-O., Cole, P., & Trichopoulos, D. (2011). Epidemiology and etiology of Parkinson’s disease: A review of the evidence. European Journal of Epidemiology, 26(S1), 1–58. https://doi.org/10.1007/s10654-011-9581-6

What is Pulmonary Artery Pulsatility Index (PAPi)?

Introduction

The Pulmonary Artery Pulsatility Index (PAPi) is a measure of right ventricular (RV) function derived from the pulmonary artery pressure waveform. PAPi has been increasingly used as a prognostic marker for patients with various cardiopulmonary diseases. In this article, we will discuss the significance of PAPi, its calculation, clinical utility, limitations, and future research directions.

Calculation

PAPi is calculated by dividing the difference between the systolic and diastolic pulmonary artery pressure by the mean pulmonary artery pressure.

PAPi = (systolic PAP – diastolic PAP) / mean PAP

Mean pulmonary artery pressure is calculated as diastolic PAP + 1/3 (systolic PAP – diastolic PAP).

PAPi can be measured invasively using a pulmonary artery catheter or non-invasively using echocardiography.

Clinical utility

PAPi is an indicator of RV afterload and function. A PAPi value of less than 1.0 indicates reduced right ventricular (RV) systolic function and is associated with increased morbidity and mortality in several conditions, such as pulmonary hypertension, acute respiratory distress syndrome (ARDS), and heart failure with preserved ejection fraction (HFpEF). Conversely, a PAPi value greater than 1.0 suggests preserved RV function and has been associated with better outcomes in patients with pulmonary hypertension and ARDS.

In patients with RV failure, PAPi is typically low due to increased RV afterload and impaired RV function. In contrast, in patients with normal RV function and low RV afterload, PAPi is typically high.

PAPi has been studied in various cardiopulmonary diseases, including acute respiratory distress syndrome (ARDS), pulmonary embolism, pulmonary hypertension, and heart failure:

  • In patients with ARDS, low PAPi values are associated with increased mortality, longer duration of mechanical ventilation, and increased risk of barotrauma.
  • In patients with pulmonary embolism, low PAPi values are associated with increased mortality, while high PAPI values are associated with a lower risk of mortality.
  • In patients with pulmonary hypertension, PAPi is a useful predictor of response to vasodilator therapy.
  • In patients with heart failure, low PAPi values are associated with increased mortality and morbidity.

Limitations

Although PAPi has shown promise as a prognostic marker, there are limitations to its use.

  1. PAPi is highly dependent on accurate measurement of pulmonary artery pressures, which can be affected by various factors such as catheter positioning, respiratory variation, and patient position.
  2. PAPI may not accurately reflect RV function in patients with RV hypertrophy or dilation, as these conditions can alter the shape of the pulmonary artery waveform.
  3. PAPi does not take into account other factors that can influence RV function, such as RV contractility, heart rate, and preload.

Future research

Despite its limitations, PAPi remains a promising marker of RV function and prognosis in various cardiopulmonary diseases. Future research should focus on improving the accuracy and reproducibility of PAPi measurements, identifying the optimal cutoff values for various diseases, and determining the clinical utility of PAPi in guiding therapeutic interventions. Additionally, further studies are needed to investigate the impact of interventions that improve RV function, such as inhaled nitric oxide or mechanical ventilation strategies, on PAPi values and patient outcomes.

Conclusion

PAPi is a useful marker of RV function and prognosis in various cardiopulmonary diseases. It is calculated by dividing the difference between systolic and diastolic pulmonary artery pressures by mean pulmonary artery pressure. PAPi has limitations, including dependence on accurate measurement of pulmonary artery pressures and the inability to account for other factors that can influence RV function. Despite these limitations, PAPi remains a promising tool for guiding therapeutic interventions and predicting outcomes in patients with cardiopulmonary diseases.


References:

  1. Chemla D, Hebert JL, Coirault C, et al. Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans. Am J Physiol. 1998;274(2 Pt 1):H500-H505. doi:10.1152/ajpheart.1998.274.2.H500
  2. Galiè N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Respir J. 2015;46(4):903-975. doi:10.1183/13993003.01032-2015
  3. Michelakis ED, Gurtu V, Webster L, et al. Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients. Sci Transl Med. 2017;9(413):eaao4583. doi:10.1126/scitranslmed.aao4583
  4. Saouti N, Morshuis W, van den Bergh Weerman MA, et al. Non-invasive assessment of pulmonary artery pressure by Doppler echocardiography in connective tissue disease patients: a systematic review. Rheumatology (Oxford). 2013;52(6):1030-1042. doi:10.1093/rheumatology/kes420
  5. Tedford RJ, Hassoun PM, Mathai SC, et al. Pulmonary arterial pulsatility index is associated with right ventricular failure in patients with pulmonary hypertension. Circulation. 2012;126(20):2563-2572. doi:10.1161/CIRCULATIONAHA.112.114066

What is a Patient Advocate?

As patients, you put a lot of trust in healthcare system to take care of you or your loved ones and make the right decisions for your health. However, sometimes the healthcare system can be complex and overwhelming, making it difficult to understand and navigate. This is where patient advocates come in.

Patient advocates are professionals who work to protect the rights of patients and help them make informed decisions about their healthcare. In this blog, we’ll explore: what a patient advocate is, what they do, and why it’s important to hire one.

What is a Patient Advocate?

A patient advocate is a trained professional who acts as a liaison between the patient and the healthcare system. They work to help patients navigate the complexities of the healthcare system, including understanding their diagnosis, treatment options, and insurance coverage. Patient advocates are often hired by patients, or their families, to ensure that the patient’s needs are met and their rights are protected.

What Does a Patient Advocate Do?

Patient advocates perform a variety of tasks to help patients and their families navigate the healthcare system. These tasks may include:

  1. Explaining medical terminology and procedures in terms that the patient can understand.
  2. Helping patients understand their diagnosis, treatment options, and insurance coverage.
  3. Facilitating communication between the patient and their healthcare physician.
  4. Advocating for the patient’s rights and preferences.
  5. Providing emotional support and counseling to the patient and their family.
  6. Coordinating care and services among consultants the primary care physician.
  7. Reviewing medical bills and insurance claims for accuracy.

It’s important to note that patient advocates do not provide medical advice or treatment. Rather, they work alongside physicians and hospitals to help patients make informed decisions about their care.

Why Hire a Patient Advocate?

There are several reasons why hiring a patient advocate may be beneficial:

  1. Expertise: Patient advocates are knowledgeable about the healthcare system and can help patients navigate it effectively.
  2. Empowerment: Patient advocates empower patients to make informed decisions about their healthcare and advocate for their rights.
  3. Time-saving: Patient advocates can save patients time by coordinating care and services among multiple physicians and consultants.
  4. Emotional support: Patient advocates provide emotional support to patients and their families during a difficult time.
  5. Cost-effective: Patient advocates can review medical bills and insurance claims for accuracy, potentially saving patients money.

How to Find the Right Patient Advocate?

  1. Ask for referrals: Talk to your physician or other patients who have used a patient advocate. They may be able to provide you with referrals and recommendations.
  2. Check credentials: Ensure that the patient advocate you are considering has appropriate education, training, and certification. Some patient advocates have extensive personal experience in health care such as physicians, nurses, nurse practitioners. While other may have received an education from a patient advocacy program.
  3. Interview multiple advocates: Interview at least three patient advocates to find the one that best fits your needs. Ask about their experience, credentials, and how they charge for their services.
  4. Consider their specialties: Some patient advocates may have specialties in specific health conditions, types of care, or areas of expertise. Consider finding an advocate who specializes in your specific needs.
  5. Evaluate communication skills: Ensure that the patient advocate is an effective communicator and has the ability to explain medical information in a way that you can understand.
  6. Check for conflicts of interest: Ensure that the patient advocate has no conflicts of interest, such as receiving financial incentives from a particular healthcare system or facility.

How Does a Patient Advocate Charge for their service?

Patient advocates may charge for their services in different ways, depending on the nature and complexity of the case, as well as their own preferences and business model. Here are some common ways that patient advocates charge for their services:

  1. Hourly rate: Some patient advocates charge an hourly rate for their time and expertise, similar to other healthcare professionals. The hourly rate can vary widely, depending on the advocate’s experience, location, and the services provided.
  2. Flat fee: Some advocates may charge a flat fee for a specific service, such as helping with insurance claims or medical billing. This fee can be negotiated in advance and is typically based on the estimated time and effort required to complete the task.
  3. Retainer: Some patient advocates may require clients to pay a retainer fee upfront, which is used to cover future services. The retainer fee can vary widely, depending on the advocate’s experience and the complexity of the case.
  4. Percentage of savings: In some cases, patient advocates may charge a percentage of the savings they are able to achieve for their clients, such as negotiating lower medical bills or insurance claims. This arrangement can be beneficial for clients who are struggling with high medical costs.

It’s important to discuss payment options with a patient advocate before hiring them to ensure that you understand their fees and that they align with your budget and needs. Some advocates may offer sliding scales or other payment arrangements to make their services more affordable for clients.

In conclusion, patient advocates are an essential part of the healthcare system. They work to protect the rights of patients and help them navigate the complexities of the healthcare system. By hiring a patient advocate, you can feel more empowered, informed, and supported during a challenging time.

Let’s talk about it!

I know. It’s not easy to talk about it. Most people don’t want to talk about it. But we all know that we can’t skip it, by simply not talking about it.

You guessed it right. I mean end of life discussion. It is an uncomfortable and unsettling topic to discuss. How could someone discuss their own death or talk about their loved one’s death while everything is normal.

“I’m still young.”

“I’m healthy and fit.”

“I eat good food, exercise and just completed my annual physical exam and everything is normal.”

“I still have time. We can talk about it later.”

That’s what many say to themselves to stay away from this topic. Unfortunately, I admit patients every day that did not tell their family their wishes, and now they can’t. Because they are very sick, on ventilator and cannot make decisions. When I ask the family about their wish, they don’t know what to do. It makes it extremely difficult and emotionally challenging for them to make a decision.

Having end of life conversations with family members is not an easy topic to discuss, but it is an essential part of ensuring that your wishes are known and respected in the event that you are unable to make decisions about your care. These conversations involve discussing your goals of care, code status, and preferences for aggressive medical care. It’s important to be specific about the types of treatments you want or don’t want, as well as any religious or cultural beliefs that may impact your decisions.

One important topic to discuss is code status. A “do not resuscitate” (DNR) order means that if your heart stops or you stop breathing, medical staff will not perform CPR or use a ventilator or other life support machines to try to revive you. It’s important to make sure that your family members and physicians are aware of your code status and understand what it means for your care.

Another important topic to discuss is the use of a ventilator or other life support machines. These machines can help you breathe and support other bodily functions, but they can also prolong the dying process and may not always align with your goals of care. It’s important to discuss your preferences for the use of these machines and whether or not you would want them used in certain situations.

In the event that you are unable to make decisions about your care, it’s important to have a designated healthcare proxy or decision-maker who can speak on your behalf. This person should be someone who understands your wishes and can communicate them clearly to physicians and nurses. They should also be prepared to make difficult decisions and advocate for your wishes, even if they may differ from their own beliefs.

When discussing end of life conversations with your family, it’s important to emphasize the importance of living well and how aggressive medical care may impact your quality of life. By being specific about your preferences, code status, and use of life support machines, you can ensure that your wishes are known and respected. It’s also important to revisit these conversations periodically to ensure that your wishes remain the same or to update them as needed.

In summary, having end of life conversations with family members is an essential part of ensuring that your wishes are known and respected. Discussing your goals of care, code status, and preferences for aggressive medical care, as well as having a designated healthcare proxy, can provide peace of mind for both you and your loved ones. By living well and being specific about your wishes, you can ensure that you receive the care you want and avoid unnecessary interventions at the end of life.

What to ask in the ICU?

Admission to the ICU can be an overwhelming and uncertain experience, both for patients and their loved ones. In my previous discussions, I covered what the ICU is and what typically occurs during a stay there. Now, it’s important to consider what questions to ask the ICU team to better understand the process and actively participate in the care. By asking the right questions, you can gain a clearer picture of what to expect, and work collaboratively with the ICU team to ensure the best possible outcome for yourself or your loved one.

Share your contacts

When a loved one is admitted to the ICU, it’s important to ensure that the medical team has the correct phone number to contact the family in case of any updates or emergencies. Often, patients assume that providing their family’s phone number during admission means that it’s automatically registered in their medical chart and accessible to everyone. Unfortunately, this is not always the case, and the information can sometimes be overlooked or misplaced. Therefore, it’s a good idea to double-check with the ICU team and make sure that the contact information is accurate and up-to-date, to avoid any delays or miscommunication during a stressful and challenging time.

Ask their contacts

Getting updates on a loved one in the ICU can be a challenging and stressful process, especially if you’re unfamiliar with the hospital’s procedures. Typically, when you call the hospital, you’ll be directed to the ICU, and from there, you’ll need to ask for your loved one’s nurse to get updates, ask questions, or provide any necessary information. This process can be time-consuming and frustrating, but there’s a simpler way. Always ask the patient’s nurse or unit secretary about how to contact the ICU directly. In many cases, they can provide you with a direct phone number to the unit or even a nurse’s phone number, so you can communicate more easily and get the information you need without the added stress.

Get the Privacy Code

Hospitals follow strict guidelines to ensure that patient information is kept confidential in accordance with the Health Insurance Portability and Accountability Act (HIPAA). One of these measures is providing a privacy code to the patient’s family. This unique code must be provided when calling the ICU to obtain updates or information about the patient. Without this code, the ICU team is unable to provide any details, as it is crucial to protect the patient’s privacy and comply with HIPAA regulations. Therefore, it’s important to ensure that you have the privacy code handy and ready to provide when contacting the ICU to receive information about your loved one’s condition.

Learn the Visitation Policy

Visiting a loved one in the ICU is an essential part of providing support and staying informed about their care. However, it’s important to understand that each hospital and ICU has its own visitation policy. Some hospitals have an open ICU policy, which means you can visit your loved one at any time. However, some hospitals may limit visitation during shift changes or at night, and there may be exceptions to regular visitation policies due to issues like the COVID-19 pandemic. To avoid any confusion or inconvenience, it’s crucial to ask the ICU team about the visitation policy and any exceptions that may apply.

Additionally, many ICUs have an age limit for visitors, usually prohibiting young children from entering the unit. It’s important to ask about the age cutoff before bringing younger family members to the ICU, as this policy is in place to protect them from hospital-acquired infections. By understanding the visitation policy, you can plan your visits accordingly and ensure that you are providing the best support for your loved one while keeping everyone safe and healthy.

Meet the intensivist

To be an effective advocate for your loved one in the ICU, you need to know when and how to communicate with the medical team. Ask about the best time to meet with the intensivist managing your loved one’s care. Many hospitals allow family members to participate in daily multidisciplinary rounds (MDRs), which provide an excellent opportunity to gather information about your loved one’s condition and treatment plan.

If your ICU permits participation in MDRs, make every effort to attend. This is the most critical time to obtain information about your loved one’s care, as the ICU team will discuss the entire treatment plan in detail. Additionally, some hospitals set aside a specific “family round” time, usually 1-2 hours in the afternoon, during which the intensivist meets with family members to provide updates and answer questions.

It’s crucial to ask about these opportunities and attend the meetings as much as possible. ICU physicians are often busy with emergencies, and the designated time for family discussions may be your only chance to get the information you need to effectively advocate for your loved one.